SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM T-1

STATEMENT OF ELIGIBILITY UNDER

THE TRUST INDENTURE ACT OF 1939 OF A

CORPORATION DESIGNATED TO ACT AS TRUSTEE

Check if an Application to Determine Eligibility of

a Trustee Pursuant to Section 305(b)(2) ✓

U.S. BANK NATIONAL ASSOCIATION

(Exact name of Trustee as specified in its charter)

31-0841368

I.R.S. Employer Identification No.

Bradley E. Scarbrough

U.S. Bank National Association

633 West 5^th

Street, 24^th Floor

Los Angeles, CA 90071

(213) 615-6047

(Name, address and telephone number of agent for service)

XERIS PHARMACEUTICALS, INC.

(Issuer with respect to the Securities)

Senior Debt Securities

(Title of the Indenture Securities)

FORM T-1

Comptroller of the Currency

Washington, D.C.

Yes

None

2

SIGNATURE

Pursuant to the requirements of the Trust Indenture Act of 1939, as amended, the Trustee, U.S. BANK NATIONAL ASSOCIATION, a national banking association organized and existing under the laws of the United States of America, has duly caused this statement of eligibility and qualification to be signed on its behalf by the undersigned, thereunto duly authorized, all in the City of Los Angeles, State of California, on the 25th day of June, 2020.

Exhibit 2
Office of the Comptroller of the currency
Washington, DC 20219
CERTIFICATE OF CORPORATE EXISTENCE
I, Joseph Otting, Comptroller of the currency, do hereby certify that:
1. The Comptroller of the currency, pursuant to Received statutes 324, et seq, as amended, and 12 USC 1, et seq, as amended, has possession, custody, and control of all records pertaining to the chartering, regulation, and supervision of all national banking associations.
2. “U.S. Bank National Association,” Cincinnati, Ohio (Charter No: 24), is a national banking association formed under the laws of the United States and is authorized thereunder to transact the business banking on the date this certificate.
IN TESTIMONY WHEREOF, today,
February 24, 2020, I have hereunto
Subscribed my name and caused my seal of office to be affixed to these presents at the U.S. Department of the Treasury, in the City of Washington, District of Columbia.
Comptroller of the currency

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Exhibit 3
Office of the Comptroller of the currency
Washington, DC 20219
CERTIFICATE OF FIDUCIARY POWERS
I, Joseph Otting, Comptroller of the currency, do hereby certify that:
1. The Office of the Comptroller of the currency, pursuant to Received statutes 324, et seq, as amended, and 12 USC 1, et seq, as amended, has possession, custody, and control of all records pertaining to the chartering, regulation, and supervision of all national banking associations.
2. “U.S. Bank National Association,” Cincinnati, Ohio (Charter No: 24), was granted, under the hand and seal of the Comptroller, the right to act in all fiduciary capacities authorized under the provision of the Act of congress approved September 28, 1962, 76 stat . 668, 12 USC 92a, and that the authority so granted remains in full force and effect on the date of this certificate.
IN TESTIMONY WHEREOF, today,
December 10, 2019, I have hereunto
Subscribed my name and caused my seal of office to be affixed to these presents at the U.S. Department of the Treasury, in the City of Washington, District of Columbia.
Comptroller of the currency

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Exhibit 6

CONSENT

In accordance with Section 321(b) of the Trust Indenture Act of 1939, the undersigned, U.S. BANK NATIONAL ASSOCIATION hereby consents that reports of examination of the undersigned by Federal, State, Territorial or District authorities may be furnished by such authorities to the Securities and Exchange Commission upon its request therefor.

Dated: June 25, 2020

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Exhibit 7

U.S. Bank National Association

Statement of Financial Condition

As of 3/31/2020

($000’s)

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